9/4/2023 0 Comments Fomepizole![]() The overall costs of both therapies should be considered and not just the upfront drug costs. ethanol, the additional expenses associated with ethanol therapy mean that fomepizole is often cheaper, particularly in pediatric patients due to the lower total doses of fomepizole. Despite the higher drug cost of fomepizole vs. ![]() Fomepizole therapy on a GM ward would have cost $4937. A 27 year old female weighing 65 kg with EG poisoning was treated with IV ethanol on ICU for 44 hours, costing $7092. Ethanol therapy on PICU would have cost $7092. Two recent case examples: A 2 year old child weighing 14 kg who ingested methanol was treated with 390 mg of fomepizole over 50 hours on a GM ward, the total cost was $1469. 3 days ethanol therapy on ICU costing $10367. Thus a 3 day course of fomepizole for a 70 kg adult on a GM ward would cost $7673 vs. A box containing 5 x 100 mg vials of Fomepizole OPi is $667. A critical care bed day costs US$3093 compared to a GM ward bed day cost of US$468. ![]() These cases can be complex with a number of variables including treatment duration and patient weight, which greatly influence costs, we have therefore included two recent real case examples. the costs of fomepizole and a general medical (GM) ward bed for a patient treated with fomepizole. These include the costs of ethanol, a critical care bed and 2 hourly ethanol assays for a patient treated with ethanol vs. Costs were based on treating a patient at a teaching hospital in central London (UK). This study aims to compare the real costs of these two antidotes in the management of EG poisoning. ![]() Ethanol therapy requires critical care nursing and frequent ethanol assays, which also have associated costs. It is expensive and so hospitals can be reluctant to stock it. Fomepizole offers many potential advantages over ethanol as an antidote for ethylene glycol (EG)/methanol poisoning. ![]()
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